I am a second year doctoral student in the Genetics, Genomics, and Bioinformatics (GGB) program at the University of Alabama at Birmingham (UAB), working under the mentorship of Dr. Rui Lu. My primary research focus lies in understanding the intricate stepwise epigenetic modifications underlying the emergence of acute myeloid leukemia (AML) and critical oncogenic pathways. To achieve this goal, I utilize a comprehensive approach that leverages the latest CRISPR/Cas9 genome editing techniques, high-throughput sequencing of epigenetic modifications, genome-wide epigenomic profiling, single-cell transcriptomics, and integrative bioinformatic analysis.

I primarily use R and Linux scripts for data cleaning, data wrangling, visualization, and exploratory analysis. I also write Snakemake workflows, to make my analysis more reproducible. Furthermore, I share my knowledge and experience with others through blog posts and github repository, such as analysis notes and snakemake pipelines for processing genomic data.

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Interests
  • Cancer Genomics
  • Epigenomics
  • Single-cell Genomics
  • Bioinformatics
  • Data Science
Education
  • PhD in Genomics and Bioinformatics, Present

    Univeristy of Alabama at Birmingham

  • B. Tech in Biotechnology, 2018

    Kathmandu University

Recent Publications

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(2022). TBX20 Improves Contractility and Mitochondrial Function during Direct Human Cardiac Reprogramming. In Circulation.

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(2021). Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia. In Blood Advances.

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(2021). Molecular Regulators of HOXA9 in Acute Myeloid Leukemia. In The FEBS Journal.

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(2021). UTX loss alters therapeutic responses in KMT2A-rearranged acute myeloid leukemia. In Leukemia.

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(2018). Development of Cost Optimized Horizontal Gel Electrophoresis Running Unit for Developing Countries (Nepal). In Nepal Journal of Biotechnology.

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